Researchers May Have Discovered How to Halt Alzheimer’s

Researchers have long linked inflammation in the brain to Alzheimer’s disease, but two new studies are giving them more insight into the correlation between the two. The studies from the University of Southampton in England found that inflammation in the brain increases as Alzheimer’s progresses and found a chemical to potentially slow the effects of the disease.Researchers May Have Discovered How to Halt Alzheimer's

Learn more about the study and its potential effects on future drug treatments for Alzheimer’s.

Reducing Inflammation to Halt Alzheimer’s

Two studies have given researchers more insight into the damaging effects of neuroinflammation and its role in the progression of Alzheimer’s. Researchers from the University of Southampton in England recently found that a chemical that reduces inflammation may be able to protect the memory loss and behavioral changes that accompany an Alzheimer’s diagnosis.

The studies, recently published in the journal Brain, have concluded that inflammation in the brain is not a result of Alzheimer’s, but instead a key driver, helping the disease to progress. Researchers compared the brains of people with Alzheimer’s disease to the brains of healthy individuals and found that the brains of people with Alzheimer’s had higher levels of immune cells, called microglia, suggesting brain inflammation. As Alzheimer’s progressed, researchers noted that that inflammation increased.

Another study found that a chemical, GW2580, successfully reduced memory loss and behavioral problems in mice with dementia. Researchers gave mice an inhibitor to reduce inflammation and found that Alzheimer’s stopped progressing as inflammation stopped. Some of the mice were treated with the GW2580 chemical and those mice demonstrated less memory loss and less behavioral problems than the mice who did not receive the chemical.

Exciting Discovery Could Lead to Alzheimer’s Drug Trials

Lead author of the study, Dr. Diego Gomez-Nicola, is encouraged by the findings, stating:

“We have shown a way into tackling the disease, and now it is time to progress this to the clinical set up as soon as possible.”

He went on to say, “These findings are as close to evidence as we can get to show that this particular pathway is active in the development of Alzheimer’s disease. The next step is to work closely with our partners in industry to find a safe and suitable drug that can be tested to see if it works in humans.”

The study also suggests that diet and positive lifestyle choices can be an important part of Alzheimer’s prevention. Researchers caution that it is too early to make recommendations but are encouraged and excited by the study and it’s potential impact on future Alzheimer’s treatment methods.

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Please leave your thoughts and comments

  • Susan C.

    This is great! Help is sure needed! Meanwhile, more emphasis can and should be placed on dietary changes. Too many people take the attitude of “oh, they’re old…let them eat what they want.” This is one reason my own mother is losing ground, because of sugar addition (omg!), and eating foods that I am certain she has reactions from. But she won’t listen to her family, and her doctor doesn’t address the diet. So we can only sit by and watch her decline, when she could be halting the acceleration, or even reversing, through a more nutrient-dense diet, and supplements like CoQ10, omega-3, and others.

    • Clare C

      Completely agree and share the same frustrations, Susan. My grandmother has recently been diagnosed with dementia and autoimmunity runs on my mother’s side, which is an immune reaction to inflammation. All of my Mum’s side of the family are stress heads (chronic inflammation trigger) and none of them are addressing the dietary factor. Drives me mad. Nutrition is at the root of most health issues.

      • Clare C

        p.s. with regard to sugar, I’d recommend looking up a book by a guy called Yudkin “Pure, White & Deadly” written in the 70s when they were blaming high fat diets for heart disease. And I’d also recommend watching this lecture: https://www.youtube.com/watch?v=dBnniua6-oM

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