Alzheimer’s Drug Awarded Fast-Track Status

A new Alzheimer’s drug has been fast-tracked by the Food and Drug Administration. The drug is being codeveloped by two pharmaceutical companies, partnering to fight the high failure rate of previous Alzheimer’s drugs.Alzheimer's Drug Awarded Fast-Track Status

Learn more about why this drug has been fast-tracked and why researchers are hopeful that this drug could hold the key for an Alzheimer’s cure.

Pharmaceutical Companies Partner to Develop Alzheimer’s Drug

Over 5.3 million Americans are living with Alzheimer’s disease. There is currently no cure or treatment plan for the disease. As the epidemic rages, pharmaceutical companies AstraZeneca PLC and Eli Lilly & Co. are working together to codevelop a drug labeled AZD3293 that may prevent the formation of beta-amyloid in the brain.

The drug is part of a new class of drugs, called BACE inhibitors, which aim to stop the production of beta-amyloid. Beta-amyloid plaques are toxic proteins that are found in the brains of people living with Alzheimer’s and are widely considered to be the main cause of the disease.

To be awarded fast-track status means that the FDA believes the drug “could fulfill an unmet need in a serious condition.”

It also means that the pharmaceutical companies involved will have increased access to the FDA while the drug is being developed and tested, reducing the time it would take for the drug to reach the market, if successful.

There is still an uphill battle for AZD3293. Historically, there has been a high level of failure for Alzheimer’s drugs, with 123 Alzheimer’s drug failures between 1998-2014 and only four medicines approved during that time. Eli Lilly and AstraZeneca hope to move the drug to final stage of testing in patients who are in the early stages of Alzheimer’s.

Would you consider being in a clinical trial to test the effectiveness of an Alzheimer’s drug like AZD3293? Share why or why not with us in the comments below. 

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Please leave your thoughts and comments

  • connie r

    yes, I would be interested to test. My mother had alzheimer’s. She had several disease during her life including Macular Degeneration, Glaucoma, Rheumatoid Arthritis, OsteoArthritis. All of these diseases, I have inherited, and at a younger age than she was.

    My brother and sister do not have any of these diseases and have definite differences to me. i.e. both were born premies, both have blue eyes and blonde hair, both have skin that tans, neither have eye problems or arthritis. I was a 9 lb baby, I have brown eyes, I have very little pigment and never tan. Both siblings have many traits of my paternal side, I have traits of my maternal side.

    In addition, I have had 3 TIAs diagnosed and showing white spots, but no lasting effects. I believe my memory is getting worse and my primary doctor agreed to testing in the future after eliminating other reasons for the memory loss.

    If there is a new drug to keep me from getting Alheimer’s, I would like to be in the trials and possibly benefit from what is learned.

    Thank you,
    CJR

  • Ron A Evans

    I submitted myself for a trial seeking pre-MCI candidates with a strong family history of Alzheimer’s disease but was declined due to experiencing outbreaks of lesions on my scalp 15 years ago when I was in my mid 50s, even though the problem was subdued and is under control. I’d be happy to be included in an appropriate trial, one that is focussed on prevention.

  • Sherri

    I would let my dad take part in the trial azd3293, he has the first stage of Alzheimer’s. And he did a trial for chemo he had melanoma an the chemo worked he is cancer for its amazing God is a working miracle in Drs an pharmaceuticals have a great day God bless

  • SLEEP — New research suggests a direct relationship between the increase in Alzheimer’s and the amount of restorative sleep we get. We humans tend to sleep two hours less per night than we did before electricity and artificial lights were introduced some 150 years ago, because that light disrupts our circadian rhythm. But how might sleep affect Alzheimer’s?

    As we sleep, our brains quite literally clear out the waste accumulated from the metabolic process of thought. Think of neurons like fish in an aquarium and amyloid plaques as the accumulation of fish poop, a byproduct of eating food (for neurons that’s glucose). Without a filtration system, that poop can foul the water and eventually kill the fish. But the brain doesn’t take part in the body’s lymphatic filtration system and relies on It’s own.

    The lighting issue is important because the pineal gland in the brain produces less melatonin with age, leading to shorter sleep. But melatonin is also the body’s most powerful antioxidant to fight oxidative stress, so having less also impacts other biological functions.

    My Bias — I’m the founding editor of Modern Health Talk but also work with Dr. Bruce Meleski at Intelligent Sleep, an Austin sleep wellness center. My sleep interests come from its significant impact on health, safety and performance.

    • lewlorton

      That there is a relationship is meaningless. Ice cream sales correlates very closely with number of murders. Number of pirates and global warning. Look at http://www.tylervigen.com/spurious-correlations to read some funny ones.
      What must be established is causation.

  • Victoria

    I would be interested depending on the side effects and possible long term harm vs the good. I would still be interested in being in this trial if there were no long term consequences and if the drug did not potentially work but at least had some preventive possibilities.

    This below article is very interesting as I have always suspected that sleep deprivation due to snoring partners has a LOT TO DO w developing dementia/Alzheimer’s…
    Thank you.
    Victoria

  • Mia

    Do I qualify being 50 years young ? If yes, most definitely . I’m a good candidate for drug trials because any bad side effects from any meds shows up with me right away . Thank you

  • Susan Saint Amour

    I would be interested — would like to know better what is involved. My husband died from complications from the disease in 2008

  • Courtney Rowan

    I would sign my father up. He is interested in clinical trials and studies, and was recently diagnosed with Alzheimer’s in September.

  • Henrick moro

    Hopefully there’s hope for people around the world who are affected by Alzheimers desease. Iam interested in any information and progress for trial

  • Carol Washington

    I would be interested in signing my Dad up fro the trial.

  • Karen Gray

    My husband was diagnosed June 2014 with Alzheimer’s. I’m definitely interested in anything to stop or slow the process of this horrible disease.

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