Blood Test Detects Onset of Alzheimer’s a Decade Early

The newest blood test to detect Alzheimer’s may be able to predict the disease 10 years before symptoms occur with 100% accuracy. Researchers from the National Institute on Aging are focusing on a protein in the brain called IRS-1 that may signal the earliest stages of Alzheimer’s.Blood Test Detects Onset of Alzheimer's a Decade Early

Learn more about this study and what it means for future treatment and prevention methods.

Blood Test Detects Onset of Alzheimer’s

This year has seen the development of a few different types of blood tests that could potentially diagnose Alzheimer’s before symptoms appear. One test uses fats in the blood stream to predict dementia within three years with 90% accuracy, while the other blood test examined blood proteins and was able to predict the onset of dementia within a year with 87% accuracy.

The most recent test promises to detect Alzheimer’s earlier than any other test ever has by looking at a single protein in the brain called IRS-1, which plays a critical role in insulin signaling in the brain and is commonly defective in people with the disease.

Researchers from the National Institute on Aging, who presented the study at the Society for Neuroscience conference in Washington, D.C., gathered blood samples from 174 participants. Of the 174 participants, 70 had Alzheimer’s, 20 had diabetes and 84 were healthy. They found that the participants who had Alzheimer’s had higher amounts of the inactive form of IRS-1 and lower amounts of the active form than those adults who were healthy. The participants who were diabetic had intermediate levels of IRS-1.

The results of the study were so consistent across the board that researchers were able to look at results and predict with 100% accuracy if the person was healthy or had Alzheimer’s.

New Blood Marker Renews Hope for Blood Test to Detect Onset of Alzheimer’s

A recent study from the University of Otago has revealed another blood marker that could help diagnose Alzheimer’s through a simple blood test. Researchers found that participants with a small number of molecules found in the blood and brain called microRNAs can correctly detect Alzheimer’s with 86% accuracy.

The study involved participants that had been diagnosed with the disease, as well as neurologically healthy individuals. Researchers found that three microRNAs were different between the two groups, and detecting these microRNAs would be possible through a simple blood test. Dr. Joanna Williams who led the screening of microRNA in blood samples of participants said, “Although there are other known markers of early Alzheimer’s disease, such as an accumulation of the toxic protein beta amyloid in the brain, testing for these involves expensive or invasive procedures that can’t be used in routine clinical practice.”

Dr. Williams went on to say that, “We know that the levels of these microRNAs differ in people who have Alzheimer’s and people who don’t. So if a GP took a blood sample from a patient who was beginning to show symptoms of memory loss, what we’d do is analyze that blood and see how that patient’s pattern of microRNA compares against established patterns.”

More research is needed before a blood test can be definitively used to diagnose Alzheimer’s, but it is something researchers are working towards. They hope to not only develop a test to detect the presence of Alzheimer’s but also to find early signs of the disease, before symptoms appear, optimizing treatment options for the individual.

A Potential Breakthrough for Prevention and Treatment

Researchers hope that their findings lead to breakthroughs in treatment methods. Senior study author, Dr. Ed Goetzl said:

“My vision of the future is you have your breakfast cereal, and on one side you have a statin for cardiovascular disease, and on the other side you have three pills to prevent dementia.”

He went on to say that, “This study shows that insulin resistance is a major central nervous system metabolic abnormality in Alzheimer’s disease that contributes to neural cell damage. As insulin resistance is a known condition in type 2 diabetes… and is treatable with several classes of existing drugs, these treatments may be useful as part of a multi-agent program for Alzheimer’s.”

The blood test is still in the early stages of development and will require a larger and longer study before it can be used to detect Alzheimer’s. The lead author of the study and neuroscientist at the National Institute on Aging, Dimitrios Kapagiannis, said: “We will need replication and validation, but I’m very optimistic this work will hold.”

Do you think the newest blood test is a viable way to prevent Alzheimer’s disease? Please share your thoughts with us in the comments below.

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Please leave your thoughts and comments

  • Tom

    Oh, that,s just great….ten more years to worry!

    • Glenda

      No, not ten more years of worry, ten more years to prevent onset or find a cure.

  • Valerie

    Yes! But, at least it`s a start and providing more hope than ever we had before. Coming from a space where I`ve just this week admitted my husband of almost 50 years

    to a long term care facility after years of caring for him at home, I`d have been better prepared in all ways had we known.

  • LoveAndPeace

    YES! And I will volunteer for a study if that will help get it moving faster!!

  • Glenda

    Sign me up! I have type 2 diabetes and have been reading about the possible causal relationship between it and dementia. This inquiring mind wants to know.

    • The causal relationship is not doing everything you possibly can to get your blood sugar and insulin levels back to normal. Type 2 diabetics still make insulin until pretty far into the disease. You CAN get it back under control, though you may have to go outside mainstream medical protocol to figure out how.

  • Jenny

    Sounds so promising! After two generations already going through this dreadful disease, it would be great to know that something to stop it is on the near horizon.

  • SandiO

    This is exciting news! With my being a part of the Baby Boomer generation, that soon will be of age to display the signs of Alzheimer’s, this kind of research needs to be escalated.

  • Connie Dabel

    How do you get to be involved in this study??

  • suz

    I think this is amazing and hope to see more of this. As a young person with great concerns and medical fears I hope to see this be able to work and help people.

  • Abbi

    Is there a way to join the study? My grandmother died but had early onset Alzheimer’s.

  • thaddeusbuttmunchmd

    Olive oil and coconut oil with curry and cannabis infused in it may work Wonders!

    • Leo

      Could you link us evidence showing that cannabis (or its oil) have benefits against Alz/dementia in vivo.
      Curry? Do you mean turmeric? I know patented extracts at high doses, like Longvida, have been shown to slowly reverse amyloid-plaque. Never heard of curry, or curry with coconut/olive oil, helping for these situations.

      • thaddeusbuttmunchmd

        The Coconut oil dissolves the active part of the curry so it is absorbed from the GI Tract. And Coconut (and palm oil) are NOT Deleterious to Health. That is a Myth. As for Cannabis, both CBD and THC are Good for the Brain. Would give the CBD in the Daytime, THC at hour of sleep.

        • Leo

          I understand that the curcuminoid class of compounds found in turmeric are fat soluble, but that doesn’t mean they reach the brain at regular doses. You would have to ingest a massive amount of curcumin-infused coconut oil on a daily for it to have mildly therapeutic effect in the brain, which is why researchers have gone to great lengths to make special products that can achieve those effects. I did more research on the current science for marijuana: THC works for anxiety (but with negative side-effects), and CBD has only been “suggested” as a theoretical herb that may help “theoretical models” of Alzheimers disease. Never has it been shown to help real people, and research into developing any form of viable treatment is not even close…

          • thaddeusbuttmunchmd

            The incidence of AD in India is Quite Low, even adjusting for lifespan. They consume a LOT of Curry (they also don’t eat much meat, and have the Body Mass Index of a SuperModel.) The Greeks live to 82, on average and have about 1/17th the Dementia of the US. The Japanese live Long. On Okinawa, in particular, they are Healthy and Long-Lived, with less Dementia. Green Tea and Olive Oil are Very Healthy. I try to use Both every Day.

          • Leo

            That’s great, I also believe green tea, olives, and turmeric are good for you, but there’s a lot more to the lifestyle and diet in those countries in comparison to the US.

  • Christa

    How can I get in on this study my father has alzheimers?

  • Gail Wallingford

    My mat. Grandmother had Alzheimer’s, 2 mat. Aunts, my 80 year old mom has Alzheimer’s. 64 y/o has dementia. I’m 65 and afraid I’ll join the group. I want to be tested to know if I have the gene. Which test should I ask my PCP to order for me?

    • Lisa Douthit

      My mother and maternal grandmother, had Alzheimer’s as did at least two of grandma’s 4 brothers. I’m almost 54 (June 13) and am wondering if I should take the test, but worried if I show that I have the gene, if I will be penalized for it by insurance.

      • I don’t think there is a gene for it. That’s not what they test you for anyway. There is also not a gene for type 2 diabetes. The reason these diseases run in families is because families tend to cluster the same bad habits and the same food habits that lead to chronic disease. Alzheimer’s is now thought of in certain research circles as type 3 diabetes. It’s caused. It doesn’t just happen.

        • 2Logical

          Genes that have been associated with type 2 diabetes risk include:

          TCF7L2, which affects insulin secretion and glucose production
          the sulfonylurea urea receptor (ABCC8), which helps regulate insulin
          calpain 10, which is associated with type 2 diabetes risk in Mexican Americans
          glucose transporter 2 (GLUT2), which helps move glucose into the pancreas
          the glucagon receptor (GCGR), a glucagon hormone involved in glucose regulation

  • Fred Andersom

    Where is their information to get selected?

    • Rachel Adams

      I,too, would like to know. I want to be tested. Alzheimer’s runs rampant in my family.

  • L G

    I truly hope this come to the public soon. It is much better to know you are going to get it or could, than to be wondering every time you forget things on a regular basis…which is mostly normal. My dad had Alzheimer’s, I seem to follow him in a few health issues, which in general is not bad. But, as anyone with a parent who has had this, you worry you will get it too. A blood test for it would be amazing!!

  • jasoul

    Is this test available in India? The thought of getting Alzheimers freaks me out. My mother had it and it was horrible. I don’t want my children to suffer.

  • Vicki Hart

    I would also like to be tested. How do you get tested and where? My father has dementia as well as several members on his side of the family.

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