How Alzheimer’s Could Be Type 2 Diabetes

The link between Alzheimer’s disease and diabetes continues to grow stronger. A new study presented at the Society for Neuroscience shows that the disease may actually be the late stages of type 2 diabetes.How Alzheimer's Could Be Type 2 Diabetes

Learn more about how Alzheimer’s could be type 2 diabetes.

The Correlation Between Alzheimer’s and Type 2 Diabetes

A new study done by researchers at Albany University in New York, shows that Alzheimer’s may be the late stages of type 2 diabetes.

People who have type 2 diabetes produce extra insulin. That insulin can get into the brain, disrupting brain chemistry and leading toxic proteins that poison brain cells to form. The protein that forms in both Alzheimer’s patients and people with type 2 diabetes is the same protein.

Researcher Edward McNay at Albany University, said:

“People who develop diabetes have to realize this is about more than controlling their weight or diet. It’s also the first step on the road to cognitive decline. At first they won’t be able to keep up with their kids playing games, but in 30 years’ time they may not even recognize them.”

Alzheimer’s, Brain Tangles and Diabetes

In the past few years, the connection between the two diseases has grown stronger with each relevant study. People who develop type 2 diabetes often experience a sharp decline in cognitive function and almost 70% of them ultimately develop Alzheimer’s.

A recent study published in the journal Neurology found that people with type 2 diabetes were more likely to develop the brain “tangles” commonly see in people with Alzheimer’s disease. They found that participants with type 2 diabetes were more likely to have the brain tangles, even if they did not have dementia or memory loss.

The study evaluated over 120 older adults with type 2 diabetes and 700 people without diabetes. Some did have dementia or Alzheimer’s while others had signs of mild cognitive impairment and others had no cognitive impairment. All participants underwent MRI scans and 50% gave cerebrospinal fluid samples so researchers could measure levels of beta-amyloid and tau, two proteins that make up the tangles commonly seen in the brains of people who have Alzheimer’s. They found that overall, people with type 2 diabetes showed more thinning the brain’s cortex and had higher levels of tau protein as evidenced by the spinal fluid which demonstrates an increased level of tangles in the brain.

Senior researcher Dr. Velandai Srikanth, geriatrician at Monash University in Melbourne, Australia believes that type 2 diabetes may cause brain abnormalities that can lead to neurodegenerative conditions, like Alzheimer’s. He also cautions that while the study shows a correlation, it does not prove causation. Other common factors among people with type 2 diabetes, like obesity, chronically high blood sugar levels or even degeneration in brain tissues may be at play.

The study has a larger implication in that controlling diabetes may be a way to fight the formation of plaques in the brain. However, for now, researchers do not fully understand why diabetes would increase tau buildup.

The results of the studies reinforce the idea that Alzheimer’s and diabetes are linked and plays an important role in our brain health.

New Insight Into the Alzheimer’s and Diabetes Connection

The link between Alzheimer’s and diabetes continues to grow stronger with a new paper by Professor Melissa Schilling, a strategy and innovation expert at the NYU Stern School of Business. The paper, recently published in The Journal of Alzheimer’s Disease, found that hyperinsulinemia, caused by early or undiagnosed diabetes, obesity or prediabetes is also found in nearly half of all people with Alzheimer’s. Schilling reviewed hundreds of published articles about the pathway between insulin and Alzheimer’s, leading her to a new understanding of the connections between the two disease. She said:

“What I’ve learned from my innovation research is that specialists can become trapped in the logic of their field, so new perspectives often come from outsiders. If we can raise awareness and get more people tested for hyperinsulinemia, especially those who have been diagnosed with or who are at risk for dementia, it could significantly lessen the incidence of Alzheimer’s disease and vascular dementia, as well as other diabetes-related health problems.”

Her findings could have major implications for Alzheimer’s and diabetes detection, including,

  • Encouraging all people with dementia to be tested for glucose intolerance problems which, when detected, may slow the disease
  • Encouraging the FDA to require the glycemic index of food produces on nutrition labels
  • Testing the general population for glucose intolerance
  • Using existing testing methods to test the entire population for diabetes since 1/3 of Americans are pre-diabetic

What You Can Do Now

While more research needs to be done to confirm the relationship between the two diseases we know that eating healthy can keep diabetes away, which may keep Alzheimer’s away. The study also showed that losing weight and exercising may keep the early stages of Alzheimer’s at bay.

The following lifestyle changes can keep you from developing type 2 diabetes:

  • Eat healthy
  • Maintain a healthy weight
  • Manage blood pressure
  • Manage cholesterol
  • Regular exercise
  • Quit smoking

Were you aware about the connection between Alzheimer’s and diabetes? Will you change your health for body and mind? Share your thoughts with us in the comments below.

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Please leave your thoughts and comments

  • Brenda Carlile

    I don’t think it’s always linked to Alzheimer’s … My Dad had no sugar problem and died of Alzheimer’s

    • Robin Conner

      My Mom died from Alzheimer’
      s, she was not a diabetic.

      • Robert Conroy

        Did he ever have an HbA1C test done?

      • Kathy B

        Depending on how long ago your mom passed, my guess is that doctors did not test for type 2 diabetes. I don’t think many doctors were concerned about testing for diabetes in the elderly until fairly recently. That said, as the article notes, at least half of people who develop Alzheimers are not diabetic. But we are talking about probabilities here – and data shows that the odds of getting dementia of any type increases substantially if you have diabetes or even pre-diabetes. If we live long enough, we all will develop some degree of cognitive decline. The idea is to delay this for as long as possible and reduce the odds of severe dementia before death. Apparently, avoiding diabetes is one important strategy for improving your odds in this area.

    • Robert Conroy

      Hiw do you know that? Did he ever have an HbA1C test done? 80% chance the answer is he didn’t.

  • Linda Isaacs

    No, of course not. Nothing is ever that black and white.

  • lurker

    Tomorrow’s welding.

  • sue

    scary, what chance have I got now?

  • Mack D Jones, MD, SAAN

    If you test for OSA, you will find that these patients have underlying OSA as the cause of both diabetes and Alzheimer’s Disease. Treat with the gold standard CPAP machine and they will both improve.

    • Kathy B

      As more people are undergoing sleep studies at earlier ages, it is becoming apparent that OSA (at least mild form) is common even in young people (especially with the obesity epidemic). Treatment at an earlier age might prevent cognitive decline rather than simply treating the decline after it has started (which is too late, in my opinion). The problem with gold standard CPAP is that it is neither comfortable nor acceptable for the lifestyles of younger, active people, especially if they only have mild sleep apnea. It also is difficult for asthmatics, like myself, to use. Use of CPAP requires an established routine that cannot deviate and a fairly time consuming daily cleaning process. It is not convenient for regular travelers (especially when travelling to developing nations), people who don’t have established daily routines for any number of reasons (work, social life), serious campers/hikers, people with pets (who chew on the wires), people with small children (who disrupt your routine), or people who are still “dating.” The insurance policies held by many people under 65 do not cover all or part of the cost of CPAP, especially the more convenient, comfortable, portable types. Research is needed to develop a better treatment for OSA than clunky, expensive, CPAP machines.

  • Loretta Pallas

    Two or my sisters have a diagnosis of Alzheimer’s – one has died and the other still living- both younger than I! This connection has been studied for years and there is a connection between insulin or the lack of and Alzheimer’s – not sure what the solution is but know that diet and exercise is all we can do now to prevent this disease! Neither of my sisters had diabetes but I still believe their is a connection with insulin and Alzheimer’s – some say when the “mystery” is solved -it will be classified at Type III diabetes!

    • Mandy

      Do you have diabetes?

    • Robert Conroy

      How do you know they didn’t have diabetes? The common fasting glucose test fails to diagnose 80% of diabetics. Only an HBA1C test is accurate. UCLA just published a study of Californians stating 46% of adult Californians are in pre-diabetes and 90% don’t know they have it. 70% will go on to develop full type 2 diabetes. Other studies show over 50% of type 2 diabetics will develop dementia and 70% will die of heart attack.

      • Kathy B

        Again, interesting comment. Doctors normally do not offer the HBA1C test. Is it covered by most insurance providers? Would it be considered part of a routine physical at a certain age (which would increase the chances of insurance coverage)?

  • Mandy

    I hate to disagree here but diabetes is a disease in which the body fails to produce enough insulin which causes elevated levels of glucose in the blood.

    • nico

      isn’t there type 1 and type 2 diabetes?insulin-dependent and non-insulin dependent where there is failure of insulin uptake in the relevant cells resulting in some of it ending up in the brain perchance?

      • Robert Conroy


    • Angie

      Thereo are different types of diabetes, type one is an autoimmune disease where the body no longer produces insulin, formally known as juvinile diabetes. Type 2 is when the body can no longer process the insulin that the body creates. This can usually be controlled with diet and exercise. Gestational affects pregnant women. There are other types usually caused by other medical conditions and their treatments. Diabetes affects every single organ in the boday. Especially the brain, sugar is what the brain needs to survive. Everything you eat the body converts to sugar to feed your brain so your brain can supply energy to your body. Just so you know I am Type 1 diabetic, and have been living with the disease for almost 18 years. This idea makes sense to me cause I have felt the effects of too much sugar and too little sugar on the brain. So the long term effects being dementia of some form makes perfect sense.

    • Robert Conroy

      Your wrong. It’s type 1 diabetes that is insulin insufficiency. Type 2s usually produce much more insulin than someone without diabetes because they have insulin resistance. Too much insulin is toxic to the cells in your body so your cells start closing the door that lets insulin into the cells. Then to try to lower blood sugar(glucose), your body has to produce more and more insulin to keep blood sugars in check. Then your blood sugars start rising and you body produces more insulin, which creates higher insulin resistance. Then maybe you get diagnosed and they give you diabetes drugs, which just raises your insulin resistance even more. Then you need more and more drugs.

  • Resist_Tyranny


  • Vicky

    My father who suffers from non-alzheimers dementia had a serious episode where he got lost driving. It took hours to find him many miles away. A neurologist did many tests and told my mother that his blood sugar was off the charts – high. I truly believe the two are related!

    • Robert Conroy

      Was he on a cholesterol (statin) drug? These are known to cause trancient global amnesia and in a post menopausal female increasrs risk of type 2 diabetes by 61% and 50% for the rest of us.

      • Kathy B

        That’s interesting. I am taking HRT post-menopausally because I recognized that every time I went off the hormones, my blood pressure and (to a lesser degree) cholesterol increased significantly. Also, two friends the same age as me (mid-50s) who are intelligent, educated women who exercise regularly and have no other risk factors already have been diagnosed with cognitive decline. Neither one takes HRT. I think a lot of women who go off or don’t take HRT without any specific health or family history reasons, end up on more medications, including statins. Many of these meds, I believe, potentially have more dangerous long term effects than HRT. As you have pointed out, this is the case with statins.

  • Cyn

    Artificial sweeteners can, with prolonged use, cause glucose intolerance. Is this connection/correlation being researched???

  • June payne

    My husband was diagnosed with Alzheimer’s 6 years ago at 57 and recently has lost a stone in weight and has just been diagnosed with diabetes with no record of it in his family – his levels of sugar are very high although he has a good diet – have no ideas as to what the outcome can be be suggests the link very strongly between the 2 conditions are likely

  • Lasantha Rupasingha

    These are very valuable information keep going…….for more details click on this

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